Engineering allosteric regulation in protein kinases
نویسندگان
چکیده
منابع مشابه
Occupational hazards: allosteric regulation of protein kinases through the nucleotide-binding pocket.
Targeting the protein kinase ATP-binding pocket provides a significant opportunity for the treatment of disease. Recent studies have revealed a central activity-independent role for nucleotide pocket occupation in the allosteric behaviour of diverse kinases. Regulation of nucleotide pocket conformation with either nucleotides or ATP competitive inhibitors has revealed an added dimension to the ...
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29 Roche, P. C., Ryan, R. J. and McCormick, D. J. (1992) Endocrinology (Baltimore) 131,268-274 Atassi, M. Z., Manshouri, T. and Sakata, S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 3613-3617 Dattatreyamurty, B. and Reichert, L. E., Jr. (1992) Mol. Cell. Endocrinol. 87, 917 Acher, R. (1993) Regul. Pept. 45, 1-13 Yamano, Y., Ohyama, K., Chaki, S., Guo, D.-F. and Inagami, T. (1992) Riochem. Biophys...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2018
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aar3250